Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families
ImmuneAgent found broadly neutralizing antibodies from unsorted human B cell repertoires, with wet-lab validation across multiple virus families.
The arXiv paper reports a 60-of-110 neutralizing antibody discovery rate and 12-of-110 broadly neutralizing antibody yield from cloned candidates. Five discovered antibodies gave complete protection in a lethal influenza mouse challenge, matching the clinical-stage comparator MEDI8852. The authors say the system identified FCRL5+CD27+ atypical memory B cells as a conserved bnAb reservoir and hydrophobic interface enrichment as a cross-viral structural signature. It also found hMPV cross-neutralizing and HPV-neutralizing antibodies without antigen-specific sorting. ArXiv · AI/CL/LG's note
The arXiv paper reports a 60-of-110 neutralizing antibody discovery rate and 12-of-110 broadly neutralizing antibody yield from cloned candidates. Five discovered antibodies gave complete protection in a lethal influenza mouse challenge, matching the clinical-stage comparator MEDI8852. The authors say the system identified FCRL5+CD27+ atypical memory B cells as a conserved bnAb reservoir and hydrophobic interface enrichment as a cross-viral structural signature. It also found hMPV cross-neutralizing and HPV-neutralizing antibodies without antigen-specific sorting. ArXiv · AI/CL/LG's note
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