Screening of Biosecurity Features in Metagenomic Data with Evo 2 Probes
Frozen Evo 2 embeddings carried enough signal for lightweight probes to flag AMR in metagenomic data.
The paper tests linear and single-head attention probes on Evo 2 layer-26 activations, without fine-tuning the model. On held-out metagenomic sets, AMR detection reached 0.888 ROC-AUC with mean pooling and 0.977 with attention. Virulence was detectable but weaker, at 0.833 ROC-AUC. The AMR probe also worked on simulated short reads without retraining, supporting use before assembly. ArXiv · AI/CL/LG's note
The paper tests linear and single-head attention probes on Evo 2 layer-26 activations, without fine-tuning the model. On held-out metagenomic sets, AMR detection reached 0.888 ROC-AUC with mean pooling and 0.977 with attention. Virulence was detectable but weaker, at 0.833 ROC-AUC. The AMR probe also worked on simulated short reads without retraining, supporting use before assembly. ArXiv · AI/CL/LG's note
score 4